An organism's genome could be compared to a complex system of instructions that allows it not only to develop, but also to carry out all the activities essential to its survival. To do this, this genome needs to be expressed ...
Molecular & Computational biology
Dec 3, 2021
0
158
Important advances in the understanding of DNA topoisomerases are discussed in a new review led by John Innes Centre researchers.
Cell & Microbiology
Mar 16, 2021
0
9
PARP inhibitors are recently developed drugs that have shown great promise against some types of ovarian, breast, prostate and pancreatic cancer, but many patients' tumors develop resistance to the drugs. Now researchers ...
Cell & Microbiology
Jan 19, 2021
0
24
An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light. The investigators at Kobe University ...
Molecular & Computational biology
Dec 8, 2020
0
8
Researchers from the University of Seville, in collaboration with colleagues from the Universities of Murcia and Marburg (Germany) have identified a new protein that makes it possible to repair DNA. The protein in question, ...
Cell & Microbiology
Oct 14, 2020
0
546
A research team from Cologne has discovered that a change in the DNA structure—more precisely in the chromatin—plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl ...
Cell & Microbiology
Oct 13, 2020
0
283
Sometimes, when something is broken, the first step to fixing it is to break it even more.
Biotechnology
Jun 22, 2020
0
27
Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research published today in eLife.
Molecular & Computational biology
Mar 24, 2020
0
430
Scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich have developed a tool to eliminate essential proteins from cells with a flash of light. The new method makes it possible to study the function of essential proteins.
Biotechnology
Jan 21, 2020
0
23
If a bone breaks or a tendon snaps, you know to seek treatment immediately. But your most fragile and precious cellular commodity, chromosomal DNA, breaks with astounding frequency—some estimate as many as 10,000 times ...
Biotechnology
Dec 2, 2019
0
126
