Biologists' mapping method illustrates paths to new proteins

Scientists at The University of Texas at Dallas are using machine learning to study proteins—the molecules that carry out essential life functions—in a way that could impact protein engineering, human health and the evolutionary ...

How 'extracellular chaperones' help remove abnormal proteins

Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer's.

PeSTo: A new AI tool for predicting protein interactions

Scientists at EPFL have developed PeSTo, an AI model that can predict, with high confidence, the binding interfaces of proteins when they bind other proteins, nucleic acids, lipids, ions, and small molecules. The model's ...

Speeding up drug discovery with diffusion generative models

With the release of platforms like DALL-E 2 and Midjourney, diffusion generative models have achieved mainstream popularity, owing to their ability to generate a series of absurd, breathtaking, and often meme-worthy images ...

More cancers may be treated with drugs than previously believed

Up to 50% of cancer-signaling proteins once believed to be immune to drug treatments due to a lack of targetable protein regions may actually be treatable, according to a new study from the Perelman School of Medicine at ...

New insights into the mechanisms of tumor growth

In many instances, the physical manifestation of cancers and the ways they are subsequently diagnosed is via a tumor, tissue masses of mutated cells and structures that grow excessively. One of the major mysteries in understanding ...

Beyond AlphaFold: AI excels at creating new proteins

Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design.

New machine learning maps the potentials of proteins

The biotech industry is constantly searching for the perfect mutation, where properties from different proteins are synthetically combined to achieve a desired effect. It may be necessary to develop new medicaments or enzymes ...

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