National University of Singapore (NUS) pharmaceutical scientists have successfully applied all-hydrocarbon-stapling modification to improve the enzymatic stability of their previously reported β-hairpin antimicrobial peptides ...
Biochemistry
Aug 14, 2023
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1
Steric zippers are a specific type of hydrophobic packing structure that form between two adjacent layers of peptide β-sheets in amyloid and similar fibrils. These structures play a crucial role in the stability and propagation ...
Analytical Chemistry
Aug 2, 2023
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62
Antiviral therapies are notoriously difficult to develop, as viruses can quickly mutate to become resistant to drugs. But what if a new generation of antivirals ignores the fast-mutating proteins on the surface of viruses ...
Biochemistry
Aug 2, 2023
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7
A team led by scientists from the National University of Singapore's (NUS) Department of Biological Sciences in collaboration with the French Center for Scientific Research (CNRS) has successfully synthesized a special protein-mimic ...
Biochemistry
Aug 2, 2023
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1
A team of microbiologists and bioengineers at the University of Pennsylvania has tested the possibility of bringing back extinct molecules to fight modern bacteria. In their study, reported in Cell Host & Microbe, Jacqueline ...
Immune systems develop specific genes to combat common bacteria such as those found in food, new research shows.
Evolution
Jul 20, 2023
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15
Almost everyone has a bag of veggies shoved into the dark recesses of their freezer that's now essentially an unrecognizable block of ice crystals. And when thawed, foods damaged by excessive ice lose their texture and become ...
Biochemistry
Jul 19, 2023
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13
In a cutting-edge discovery, published in the Journal of the American Chemical Society, Florey scientists have solved a long-standing problem: the need for an affordable, simple way to make peptide-based drugs that hold their ...
Biochemistry
Jul 17, 2023
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61
Researchers from the University of St Andrews have developed peptides that can help combat bacteria growing in biofilms, which occur in up to 80% of human infections.
Biochemistry
Jul 6, 2023
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14
Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" ...
Biochemistry
Jun 13, 2023
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