People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus of new drug discovery.
Biochemistry
Dec 6, 2023
0
20
When considering laws, workplace policies or school rules, one might take notice of whom they impact. New research from the University of New Mexico has found whether it's interventions to reduce workplace bullying, help ...
Social Sciences
May 10, 2023
0
15
Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable. Moreover, pain medications can have side-effects such as dependence and ...
Molecular & Computational biology
Mar 4, 2023
0
53
New substances that activate adrenalin receptors instead of opioid receptors have a similar pain relieving effect to opiates, but without the negative aspects such as respiratory depression and addiction.
Biochemistry
Oct 4, 2022
0
33
Otis was our bighearted bloodhound, whom we loved dearly. He had an active life playing with our three other dogs and going for long walks every morning and evening with us. But when he was eight years old, his lifestyle ...
Veterinary medicine
Mar 16, 2022
0
15
Since the early days of social media, there has been excitement about how data traces left behind by users can be exploited for the study of human behaviour. Nowadays, reseachers who were once restricted to surveys or experiments ...
Social Sciences
Jul 12, 2021
0
4
The American Association of Feline Practitioners (AAFP) has released the updated 2021 AAFP Feline Senior Care Guidelines to be published in the July issue of the Journal of Feline Medicine and Surgery. This update provides ...
Veterinary medicine
Jun 29, 2021
1
6
Certain everyday household items can pose a threat to pets' health, says Susan Nelson, clinical professor at the Kansas State University College of Veterinary Medicine. Here are some items and situations pets owners can watch ...
Plants & Animals
Mar 26, 2021
1
11
According to a multidisciplinary study at the University of Oulu, contemporary Finns' vertebrae have not grown in the same proportion to body size compared to people who lived 200 to 500 years ago. The smaller size of vertebrae ...
Evolution
Feb 12, 2020
0
52
An international team of researchers has used nanoparticles to deliver a drug—one that previously failed in clinical trials for pain—into specific compartments of nerve cells, dramatically increasing its ability to treat ...
Bio & Medicine
Nov 4, 2019
2
1095
An analgesic (also known as a painkiller) is any member of the diverse group of drugs used to relieve pain (achieve analgesia). The word analgesic derives from Greek an- ("without") and algos ("pain"). Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (acetaminophen), the non-steroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, narcotic drugs such as morphine, synthetic drugs with narcotic properties such as tramadol, and various others.
In choosing analgesics, the severity and response to other medication determines the choice of agent; the WHO pain ladder, originally developed in cancer-related pain, is widely applied to find suitable drugs in a stepwise manner. The analgesic choice is also determined by the type of pain: for neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants.
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