First 3-D structure of the enzymatic role of DNA

DNA does not always adopt the form of the double helix associated with the genetic code; it can also form intricate folds and act as an enzyme called a deoxyribozyme. A researcher from Spain and other scientists from the ...

Computer simulations reveal the energy landscape of ion channels

Every cell of our body is separated from its environment by a lipid bilayer. In order to maintain their biological function and to transduce signals, special proteins, so called ion channels, are embedded in the membrane. ...

Protein 'filmed' while unfolding at atomic resolution

When proteins get "out of shape", the consequences can be fatal. They lose their function and in some cases form insoluble, toxic clumps that damage other cells and can cause severe diseases such as Alzheimer's or Parkinson's. ...

Achilles' heel of pathogenic bacteria discovered

Multidrug-resistant bacteria remain a major concern for hospitals and nursing homes worldwide. Propagation of bacterial resistance is alarming and makes the search for new antimicrobials increasingly urgent. Scientists at ...

Structure discovered for promising tuberculosis drug target

Researchers at Johns Hopkins have figured out the three-dimensional shape of the protein responsible for creating unique bonds within the cell wall of the bacteria that cause tuberculosis. The bonds make the bacteria resistant ...

Zooming in on bacterial weapons in 3-D

The plague, bacterial dysentery, and cholera have one thing in common: These dangerous diseases are caused by bacteria which infect their host using a sophisticated injection apparatus. Through needle-like structures, they ...

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