Cryo-EM reveals structure and mechanism of the 5-HT3 receptor

In November 2017, a Titan Krios cryo-electron microscope (cryo-EM) was inaugurated at the ESRF, the European Synchrotron, France. Data collected on this cryo-EM features in a Nature publication describing the activation cycle ...

Full-length serotonin receptor structure seen for first time

A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The tiny proteins—approximately ...

Why acid trips last so long

Ever wondered why there have been so many urban myths and songs dedicated to LSD? Molecular dynamics (MD) simulations suggest that LSD's slow binding kinetics may be due to a 'lid' formed by extracellular loop 2 (EL2) at ...

This is LSD attached to a brain cell serotonin receptor (Update)

A tiny tab of acid on the tongue. A daylong trip through hallucinations and assorted other psychedelic experiences For the first time, researchers at the UNC School of Medicine have discovered precisely what the drug lysergic ...

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