An effective sweeper closes DNA replication cycling

DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA to work as replication machineries. Among ...

A mutational timer is built into the chemistry of DNA

If you had to copy billions of letters from one sheet of paper to another, you'd probably make a few mistakes. So it might not come as a surprise that when DNA makes a copy of its three-billion-base genetic code, it can slip ...

Eukaryote process of programmed fork arrest determined

A research collaboration between the Medical University of South Carolina, the Institute of Human Genetics in France, and Howard Hughes Medical Institute at Rockefeller University has revealed the means by which cells accomplish ...

Scientists identify protein profiles of DNA repair

During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication ...

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