Scientists tame chaotic protein fueling 75% of cancers

MYC is the shapeless protein responsible for making the majority of human cancer cases worse. UC Riverside researchers have found a way to rein it in, offering hope for a new era of treatments.

New way to target 'undruggable' molecules involved in cancer

For decades, cancer researchers have longed for a way to target a set of proteins called transcription factors. While we've long known that tumors use these proteins to grow out of control, their unique configurations meant ...

Protein domain structures affect the quality of stem cells

The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...

Eliminating damaged germline cells preserves germline integrity

The germline is the cell lineage of an organism that passes on its genetic material to its progeny. Genetic damage to the germline can cause developmental defects and even death of that same progeny. It is thought that biological ...

Elusive cancer-related protein captured in flight

Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in the cell. The study, published in Nature Structural and Molecular ...

A new approach to drugging a difficult cancer target

One of the most common cancer-promoting genes, known as Myc, is also one of the most difficult to target with drugs. Scientists have long tried to develop drugs that block the Myc protein, but so far their efforts have not ...

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