The Spatial Mouse Atlas: New insights into cell fate

High-resolution gene expression maps have been combined with single-cell genomics data to create a new resource for studying how cells adopt different identities during mammalian development. The Spatial Mouse Atlas is the ...

Stem cells organize themselves into pseudo-embryos

The definitive architecture of the mammalian body is established shortly after implantation of the embryo in the uterus. The antero-posterior, dorso-ventral and medio-lateral axes of the body become organized under the control ...

Repairing DNA lesions

Repair of DNA lesions is essential for mammalian development. Notably, DNA lesions in cells caused by genotoxic agents results in arrest of cell cycle and ultimately in cell death. In response, DNA polymerase ζ (Polζ) is ...

From a drop of blood, a clone

Over the last few decades, scientists have drawn upon a powerful arsenal of biotechnology techniques to establish a wide variety of genetically engineered mouse strains. These animals represent invaluable resources for studying ...

Research reveals new understanding of X chromosome inactivation

(Phys.org)—In a paper published in the Nov. 21 issue of Cell, a team led by Mauro Calabrese, a postdoctoral fellow at the University of North Carolina in the lab of Terry Magnuson, chair of the department of genetics and ...

page 1 from 2