Basement membrane underpins tissue interactions in the skin

In a discovery that could pave the way for therapies that promote wound healing and alleviate skin diseases, RIKEN researchers have found that the network of molecules under the outermost layer of mouse skin, the skin epithelium, ...

Researchers elucidate the mechanics of cellular attachment

For cells to assemble into tissues and whole organs, the extracellular matrix (ECM) as well as integrins are required. The ECM forms a kind of extra-cellular protein meshwork; the integrins are surface proteins, which cells ...

Partial mechanical unfolding may regulate protein function

A study carried out as a collaborative approach between University of Tampere, Finland, and Imperial College London has shown that mechanically regulated proteins talin and α-catenin have stable intermediates during mechanical ...

Classical enzymatic theory revised by including water motions

Enzymes are macromolecular biological catalysists that lead most of chemical reactions in living organisms. The main focus of enzymology lies on enzymes themselves, whereas the role of water motions in mediating the biological ...

The extracellular matrix

NPL scientists have created a functional model of the native extracellular matrix which provides structural support to cells to aid growth and proliferation and could lead to advances in regenerative medicine.

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