Clams and other invertebrates often live in habitats with dense bacterial populations, despite lacking adaptive, lymphocyte-based immune systems. How clams resist bacterial pathogens in the environment is unclear.
Plants & Animals
Nov 29, 2022
0
43
An international team of researchers has developed a method for altering one class of antibiotics, using microscopic organisms that produce these compounds naturally.
Materials Science
Jul 27, 2022
0
87
Researchers from North Carolina State University have engineered designer biosensors that can detect antibiotic molecules of interest. The biosensors are a first step toward creating antibiotic-producing "factories" within ...
Cell & Microbiology
Oct 3, 2017
0
128
Like a dairy farmer tending to a herd of cows to produce milk, researchers are tending to colonies of the bacteria Escherichia coli (E. coli) to produce new forms of antibiotics—including three that show promise in fighting ...
Biochemistry
May 29, 2015
1
1168
High-resolution cryo-electron microscopy has now revealed in unprecedented detail the structural changes in the bacterial ribosome which results in resistance to the antibiotic erythromycin.
Cell & Microbiology
Oct 13, 2014
0
0
Ludwig Maximilian University researchers have used cryo-electron microscopic imaging to characterize the structural alterations in the bacterial ribosome that are required for induction of resistance to the antibiotic erythromycin.
Cell & Microbiology
Mar 28, 2014
0
0
Powerful antibiotics that scientists and physicians thought stop the growth of harmful bacteria by completely blocking their ability to make proteins actually allow the germs to continue producing certain proteins—which ...
Cell & Microbiology
Oct 25, 2012
0
0
(PhysOrg.com) -- Researchers at Tufts University School of Engineering have reported the first successful production of the antibiotic erythromycin A, and two variations, using E. coli as the production host.
Biochemistry
Nov 24, 2010
0
0
Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering ...
Biochemistry
Nov 3, 2009
0
0
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma and Legionellosis. It was first marketed by Eli Lilly and Company, and it is today commonly known as EES (erythromycin ethylsuccinate, an ester prodrug that is commonly administered).
In structure, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desosamine), making it a compound very difficult to produce via synthetic methods.
Erythromycin is produced from a strain of the actinomycete Saccharopolyspora erythraea.
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