Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.
Cell & Microbiology
Apr 17, 2024
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44
Numerous anti-cancer drugs function by targeting the DNA within cancerous cells, halting their proliferation. Yet, cancer cells occasionally develop mechanisms to repair the damage inflicted by these drugs, diminishing their ...
Molecular & Computational biology
Mar 12, 2024
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2
Our DNA undergoes constant damage and repair. The most severe damage happens when the DNA breaks into two pieces, known as a double-strand DNA break. It creates two loose DNA ends that, if left unfixed, can lead to cell death. ...
Cell & Microbiology
Feb 6, 2024
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49
The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease. However, the CRISPR/Cas9 method can also result in unintended ...
Biotechnology
Sep 15, 2023
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58
Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks—damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling ...
Biochemistry
Jul 27, 2023
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61
A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.
Cell & Microbiology
May 16, 2023
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100
We often come to an understanding of what causes a disease. We know, for example, that cancers are caused by mutations at critical locations in the genome, resulting in loss of control of cell growth. We know that the onset ...
Molecular & Computational biology
May 10, 2023
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67
A team of scientists led by Dr. Kei-ichi Takata from the Center for Genomic Integrity (CGI) within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover ...
Cell & Microbiology
Mar 16, 2023
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53
A Rice University lab is leading the effort to reveal potential threats to the efficacy and safety of therapies based on CRISPR-Cas9, the Nobel Prize-winning gene editing technique, even when it appears to be working as planned.
Cell & Microbiology
Oct 24, 2022
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23
DNA double-strand breaks are one of the biggest threats to the genome and a driving force of carcinogenesis. Cellular repair mechanisms such as homologous recombination are essential for the maintenance of genome stability ...
Cell & Microbiology
Aug 24, 2022
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